Sharon Niv: The Neurobiology of Hope—Navigating Burnout with Microdose Ketamine

Are you navigating a successful business but feeling like you’re sailing through a thick, internal fog?

For many visionary entrepreneurs, the external metrics of success—growth, revenue, and impact—don’t always match the internal reality.

You might find yourself waking up wondering if you’re drifting, despite having “made it” on paper.

If you are tired of the “cookie-cutter” systems and “proven paths” that feel like a straightjacket for your creativity, this conversation is the signal in the mist you’ve been waiting for.

In this episode of the Lighthouse Sessions, we sit down with Sharon Niv, a cognitive psychologist and the co-founder of Joyous Public Benefits Corporation. Sharon’s work represents a massive shift in how we approach mental health, moving away from high-risk, overwhelming experiences and toward a sustainable “go low, go slow” philosophy.

In this episode, we dive deep into:

The “Go Low, Go Slow” Approach: Why intentional microdosing is a gentler, skill-building alternative to the intense, insight-based “ego death” journeys that many founders find too overwhelming to integrate into their daily lives.

Creating “Spaciousness” in the Nervous System: How low-dose ketamine acts as a “psycholytic”—a mind-loosener—that provides the partial dissociation necessary to re-evaluate internal scripts and overcome a triggered, high-stress state.

The Science of Neuroplasticity: The biological reality of how ketamine promotes the birth of dendrites—the “fingers” of your neurons—physically making your brain more fertile for new mental habits and creative thought.

Graduating from Treatment: Unlike traditional models that might feel like a lifelong sentence, the Joyous protocol is designed for “graduation,” with many people finding they overcome mental ruts in five to ten months.

Personalization vs. Standardization: Why traditional SSRIs only have about a 30% likelihood of working for any given individual, whereas ketamine has shown non-specific effectiveness in over 70% of people.

The Importance of Intentionality: How assigning your time on the medicine to self-reflection, journaling, or meditation “turbo-boosts” your ability to replace burnout with sustainable growth. S

haron Niv isn’t just talking about theory; she is leading a company that has treated over 86,000 people with this unique protocol.

Whether you are struggling with moderate PTSD, anxiety, or the general “grayness” of professional burnout, this episode offers a roadmap that respects your autonomy and your unique wiring.

Stop trying to “hustle” your way out of the fog.

It’s time to find a compass that helps you navigate within the uncertainty without sacrificing the soul of what you’ve built.

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